殺粉蝶霉素A  Piericidin A
NADH-ubiquinone oxidoreductase inhibitor
Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
PRODUCT PROPERTIES
Alternative Name:
Piericidin A1, Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D
RTECS:
YD4588000
Source/Host:
Isolated from Streptomyces sp. MST-AS5364.
Solubility:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Long Term Storage:
-20°C
Hazard:
VERY TOXIC.
MW:
415.6
CAS:
2738-64-9
Formula:
C25H37NO4
Purity:
≥95% (HPLC)
Appearance:
北京普華仕科技發(fā)展有限公司
發(fā)布與
殺粉蝶霉素A Piericidin A
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